Upload Ancestry Raw Dna to 23 and Me
Since 2017, the market for consumer genomics products has been exploding.
With an estimated 20 million people having at present ordered genetic testing kits, it'south simply natural many of us are looking for means to get more from the data provided by the most popular providers like 23andme and Ancestry.
Which genes do 23andme and Ancestry study on?
Both 23andme and Beginnings offering up a express subset of genes for their customers. As the name denotes, Ancestry.com is more than focused on family lineage, whereas 23andme places a greater emphasis on health and wellness. However, it is important to realize that neither provider offers full genome sequencing. Instead they "genotype." While full genome sequencing looks at all your genes, genotyping analyzes the most studied genes (only a small fraction of the genome). You could call up of information technology this way: on a long road trip cross country, genome sequencing includes every city, no matter how small, in its final map. By contrast, genotyping picks only the major cities. We created the visual beneath to amend demonstrate the difference between sequencing the whole genome vs. genotyping.
For more information, cheque out our review of the popular genetic testing services.
It's of import to realize that the raw data you get from the major providers just offers near 0.04% of your genome. While the interface and content accent is different for different providers, Beginnings and 23andme report on a very similar subset of genes. Further, the large boys are constantly changing the game equally to which genes are included in which version of their product.
For example, Gene Nutrient is a one of the sites that will procedure raw data for you lot from 23andme or Ancestry. Office of what we do with this data is to score our clients for fat metabolism, antioxidant capacity and also more than obscure processes like histamine clearance. Based on that score, we identify people into one of 20 nutrition types and offer them access to a custom recipe database. Simply here's the kicker: 23andme and Beginnings routinely change the genes they report on from version to version, so people who bought kits earlier accept more genetic data on certain markers than exercise others. The histamine genes are a skillful case. There are more AOC1 genes in version 4 of 23andme than in that location are version 5.
Having said that, the reason there are a adept number of providers who tin can offering insights into raw data is because the files are like shooting fish in a barrel to read. They come in simple text files making it straightforward for software programs to parse and score data.
If you're looking for the top destinations to take your raw data, you lot've come to the correct place. Below, I've listed the providers I have used and trusted with my raw data.
Cistron Food
All-time for: anyone interested in learning more about nutrition
You knew we were going to include our own app, right?
For those of you interested in a resolution to the diet wars, we created our custom diet program. Dr. Aaron Gardner, our resident geneticist and caput of enquiry, drew up an algorithm that will place yous into i of 20 diet types based on your raw genetic information from 23andme or Ancestry.
For example, carriers of a gene known to increase risk for dementia, called APOE4, will ordinarily autumn into ane of our diet types that is lower in saturated fat from all sources, just especially from animal products. Those that carry more robust fat genes, only who are likely to accept problems regulating blood sugar levels, would fall into a more Paleo style of Mediterranean diet that limits carbs, particularly refined carbs. Once you have your assigned diet type, our recipe database comes alive with a system of eating that is designed for your DNA and easy to follow.
Afterwards in the report, we dive into more technical issues such equally MTHFR and methylation condition, tips for building an optimal supplement regimen, as well as sterol absorption and genes that bear on detox pathways.
LiveWello
Best for: health care professionals and their clients
LiveWello is in a category of sites that apply genetic raw information to offer insight into disease states and possible risks for serious illness. While the site tin can be a useful identify to research whether you carry an obscure genetic mark, or to share a story in one the genetics forums, overall my experience with LiveWello and Promothease was that of drinking from a fire hose. At that place is and then much information that it becomes hard to split up the adept from the highly speculative.
Having said that, if you lot are just looking for information virtually whether you lot carry certain MTHFR variants, or other more "popular" markers similar COMT, LiveWello could be just what the medico ordered.
Since LiveWello allows for the management of multiple profiles from the same account, and because of the ability to create custom genetics reports and to search by SNP, this site could also be a good option for clinicians and health care providers.
Promethease
All-time for: health care professionals and their clients
Data from Promethease is sourced from SNPedia, a big, and very technical database of genes and common polymorphisms. This is one of the genetics sites I used when I was get-go getting started with genetics research. Ahhh, the good old days of that terrible feeling where reading a genetics report completely out of context convinced me I was sure to develop X, or Y affliction. Unless y'all accept a science or genetics background, Promethease is a less user friendly LiveWello.
One prissy characteristic of the service is that you can view some sample reports without uploading your raw data. For example, here is a sample written report they link to on their homepage that uses 23andme data. Almost reports on Promethease price $12.
Again, for a geneticist or someone with deep scientific knowledge, this site may evidence very useful. For the average consumer, I think it's a stress multiplier and some other fire hose.
Genetic Genie
Best for: those just getting started on their genetics journeying, those who only want to know MTHFR status
I've always liked Genetic Genie. It's a costless report (although you take the choice to donate) that gives a concise methylation report with a solid console of SNPs to choose from. Users also have the choice of choosing their detox console, also costless. Genetic Genie is a straightforward style of using raw genetic data to get some of the top line data 23andme and Ancestry choose not to study on.
StrataGene
Best for: wellness intendance professionals and their clients
StrataGene is the encephalon kid of Dr. Ben Lynch of MTHFR and Dirty Genes fame. Dr. Lynch was one of the pioneers of nutrigenomics and is widely recognized as an authorization on using genetics every bit a tool for meliorate integrative medicine. He is likewise the founder of a supplement visitor called Seeking Health. Seeking Health is thought of as a high quality brand that sources proficient ingredients. To his credit, at least when I used StrataGene a few years back, the reports were not making supplement recommendations.
StrataGene is another study that uses raw genetic data to provide technical reports. Most consumers will not exist able to get much from these reports unless they are working with a healthcare provider.
Highlights for StrataGene are the folate cycle (methylation), methionine cycle, and transsulfuration and histamine pathways. All of the pathways are highlighted with a chart which shows the user the biochemical reactions at play driving different outcomes and where their pathway may be disrupted.
This is a study that can exist taken to a doctor versed in nutrigenomics, simply it will be too complicated for most consumers. Note for Ancestry customers, StrataGene only accepts V2.
Endmost Thoughts
The genetics globe is changing quickly. Steve Jobs was reported to have paid $100,000 to take his genome sequenced. Today, that same process would cost $1,000.
As the cost comes down and the technology evolves, full genome sequencing for anybody is probably but a few years away.
For now, the genotyping services like 23andme and Ancestry provide value, both from a health and entertainment standpoint. Extracting your raw data will give you access to a far greater range of genes than the large providers discuss in their interfaces. Still, careful the conclusions you describe from the data. In some cases, the knowledge tin can be powerful. In others, trying to slice together mechanisms even some of the best scientists have yet to understand tin leave people stressed out and confused.
Source: https://www.mygenefood.com/blog/5-trusted-sites-that-process-raw-23andme-and-ancestry-data/
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